[In vitro] Toxicity Testing in the 21st Century- The Vision and Some Questions

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  • Date 2017-04-29
[In vitro] Toxicity Testing in the 21st Century- The Vision and Some Questions



안녕하세요. CND 센터 관리자입니다.

이번에는 in vitro approach를 주제로 강연을 소개해드리겠습니다.

영상자료 대신 PPT 자료를 파일로 첨부하였습니다. 

조금이나마 학습에 도움이 되길 바랍니다.




 

Kim Boekelheide
Brown University, Providence, Rhode Island

Kim Boekelheide

The purpose of this event for postdoctoral scholars, graduate students, undergraduate students, and other invited guests is to focus on the importance of animal research to biomedical sciences and toxicology and the ethical obligations of the scientific community to follow the “3Rs” of animal testing (refine, reduce, replace) whenever it is feasible.
 

In the future, toxicity testing will utilize emerging technologies from the ongoing revolution in understanding biological processes to identify the effects of chemicals on toxicity pathways, using in vitro approaches. The interpretation of chemically-induced alterations in toxicity pathways will depend upon sophisticated modeling that extrapolates from the measured dose-response in cell-based systems to human exposure.

 

After providing an overview of the National Academy of Sciences report entitled “Toxicity Testing in the 21st Century: The Vision and Some Questions,” this presentation will turn to a discussion of issues raised by this new approach. The audience will be asked to think about and respond to the following questions:
 

  • Is focus on environmental agents important for the design criteria?
  • How long will it take to implement this new toxicity testing paradigm?
  • Is the focus on “toxicity pathways” useful or distracting?
  • Does a test for neurodevelopmental effects have to look at neurons?
  • How do we distinguish adaptive versus adverse (toxic) responses?
  • Is this a screening tool or a stand-alone system?
  • How is the new paradigm validated?
  • What about epigenetics and other new biology?
  • How do regulators handle the transition in testing?
  • How does the apical definition of adversity work in the new toxicity testing paradigm?



출처: http://www.toxicology.org/education/pw/ivLectures.asp

 
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