[In vitro] The 3Rs in Animal Use and a Prospective In Vitro Screening Tool for Identifying Potential Immunotoxicants

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  • Date 2017-06-26
[In vitro] The 3Rs in Animal Use and a Prospective In Vitro Screening Tool for Identifying Potential Immunotoxicants


안녕하세요. CND 센터 관리자입니다.

이번에는 immunotoxicants의 in vitro 접근방법을 주제로 강연을 소개해드리겠습니다.

영상자료 대신 PPT 자료를 파일로 첨부하였습니다. 


조금이나마 학습에 도움이 되길 바랍니다.


 

Courtney E. W. Sulentic
Wright State University, Dayton, Ohio

Courtney E. W. Sulentic

The purpose of this lecture is to discuss the importance of animal research to biomedical sciences and toxicology and the ethical obligations of the scientific community to follow the “3Rs” of animal testing (refine, reduce, replace) whenever it is feasible. Following this discussion the remainder of the lecture will briefly describe Dr. Sulentic’s current research utilizing an in vitro alternative to understand mechanisms in altered immune function.

The immune system is critical to human survival but also plays a contributing role in various mechanisms of toxicity. Assessing alterations of immune function by potential immunotoxicants is complicated by the diffuse nature of the immune system which is composed of various effector cells each with differing functions. Current immunotoxicity testing relies heavily on animal studies underscoring the need to develop and implement alternative approaches.

Dr. Sulentic will discuss a cell line model developed to provide an in vitro alternative to animal studies in identifying immunotoxicants that specifically target B-cell function (i.e., alteration of immunoglobulin expression and antibody secretion) as well as elucidating the mechanisms of altered B-cell function.






출처: SOT http://www.toxicology.org/education/pw/ivLectures.asp







 
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