PATHOLOGY TECHNIQUES IN RAT NEUROTOXICITY STUDIES 

HOSTED BY STP-I

CO-SPONSORED BY IFSTP AND IATP

 Held on May 11, 2015

Speaker:  Alok Sharma, BVSc, MVSc, MS, PhD, DACVP, DABT

Various pharmaceuticals drugs and environmental toxins have potential to cause neurotoxicity, which is manifested as an adverse effect on the structure and/or function of the nervous system. To screen for potential neurotoxicity in rats, a combination of techniques are used including functional observational battery (FOB), study of motor activity and histopathology. This webinar provided an overview of techniques used to detect histopathologicchanges in the central and peripheral nervous system. The speaker focused on important points to consider while designing and conducting neuropathological evaluation in rats including perfusion-fixation, collection of tissues (brain, spinal cord, dorsal root ganglia, peripheral nerves, and muscles), common embedding techniques and use of histochemical stains and immunohistochemical labels to detect histopathologicchanges. 


출처: http://www.ifstp.net/webinar_programs