[Biomarkers] SOT - Links Between Neurological Disease and Toxicity

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#Biomarker,
SOT (Society of Toxicology) 사이트에 제공되어 있는 강연 자료를 올려드립니다.

출처: http://www.toxicology.org/education/pw/lectures.asp


Biomarkers of Disease and Toxicity: Exploiting the Interconnections—2013

Chairperson(s): Donna L. Mendrick, US FDA, Division of Systems Biology, Jefferson, AR, and William B. Mattes, PharmPoint Consulting, Poolesville, MD.

With the recent focus on (a) cellular pathways involved in toxicity sequelae and (b) translational biomarkers that may link animal and in vitro model observations with clinical reality, there is a need to broaden the understanding of how experimental models may replicate human toxicity and disease processes. Multicellular organisms may have large numbers of genes and proteins, but a relatively limited repertoire in terms of pathophysiology in response to disease or toxicant exposure. This fact allows research to improve and protect human health to be founded on the use of model systems that allow for tractable experimentation. Animal models and, more recently, in vitro systems have served as a means of both exploring mechanisms and identifying hazards in terms of disease and adverse events. However, the interconnections between disease and toxicity are rarely explored leaving the information in silos. This symposium will examine organ-based toxicity and disease processes, and compare lessons learned in biomarker identification and use across toxicity, disease, and species.

 
 

Links Between Neurological Disease and Toxicity

Presenter: David Gerhold

Neurological damage may be caused by environmental agents; MPTP serves as an example, where it, as a contaminant in drugs, let users to develop Parkinson-like symptoms. Indeed nervous system toxicities and disease share common modes and pathways, and the combined use of models of neurological damage caused by drugs, toxicants, and disease may move the field forward faster in the identification and use of translational biomarkers.


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