SOT 사이트에 제공되어 있는 Eminent Toxicologist Lecture Series 입니다.

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출처: SOT (Society of Toxicology) http://www.toxicology.org/education/edu/eminent.asp


Melvin E. Andersen—“45 Years Modeling Dose-Response Relationships: An Unanticipated Career!”
 

This lecture examines my experience using quantitative models for understanding dose-response relationships, as well as touching on pharmacokinetics, pharmacodynamics, and new directions in cell pathway based models. Instead of postdoctoral work on shark hemoglobin, military service directed me to assess the toxicity of chemicals found onboard nuclear submarines. Training in modeling small and large molecule kinetics led me to question why probit analyses were used for dose response, why the logarithm of inhaled concentration is a measure of dose, and what is the relationship expected between inhaled concentration and chemical in tissue or between the amount of chemical and response? The main lessons of a long career are that models require us to state our ideas clearly and quantitatively and then to see if our ideas are correct or in need of revision. The use of these models repeatedly shows that it is even more important to know our ideas are wrong than simply to think they might be right.

 

Melvin E. Andersen Biography

Melvin Andersen, PhD, DABT, CIH, ATS, is Distinguished Research Fellow at ScitoVation LLC, Research Triangle Park, North Carolina. Previously, he was at The Hamner Institutes for Health Sciences. Over a 45-year career, he worked in government (US Navy, DoD, US EPA), industry (Chemical Industry Institute of Toxicology), academia (Colorado State University), and consulting (ICF Kaiser Consulting). Dr. Andersen introduced physiologically-based pharmacokinetic (PBPK) modeling. Other long-term interests include biologically realistic models of the uptake, distribution, metabolism, and biological effects of drugs and toxic chemicals and applying these models in safety assessments and quantitative health risk assessments. Dr. Andersen has mentored 13 graduate students and 13 postdoctoral researchers and served on an additional 11 graduate student research committees. He has served on or chaired many regulatory review panels, both domestic and international, regarding chemicals of environmental interest, including contributing to the 2007 National Academy of Sciences report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” Author/co-author of 400 peer reviewed publications, 70 book chapters, and 30 technical reports, his work has more than 18,000 citations. He has received numerous SOT awards including the Frank Blood, Achievement, Arnold J. Lehman, Best Paper of the Year in Toxicological Sciences, and Merit.