[SOT Lectures] Regenerating CNS Myelin—From Mechanisms to Medicines

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  • Date 2017-03-13
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[SOT Lectures] Regenerating CNS Myelin—From Mechanisms to Medicines



안녕하세요. CND 센터 관리자입니다.

SOT 사이트에 제공되어 있는 Toxicologist Lecture Series 중에서

이번에도 신경계를 주제로 강연을 소개해 드립니다. 

많은 도움이 되길 바랍니다. 




 

Lecturer: Robin J.M. Franklin, Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.

 

Brigitta Stockinger

Remyelination, the process by which new myelin sheaths are restored to demyelinated axons, represents one of the most compelling examples of adult multipotent stem cells contributing to regeneration of the injured CNS. This process can occur with remarkable efficiency in multiple sclerosis (MS), and in experimental models, revealing an impressive ability of the adult CNS to repair itself. However, the inconsistency of remyelination in MS, and the loss of axonal integrity that results from its failure, makes enhancement of remyelination an important therapeutic objective. There is now compelling evidence that ageing is the major contributor to the declining efficiency of remyelination and that this is largely due to a failure of stem cell differentiation. This talk will review recent studies we have undertaken aimed at obtaining a detailed understanding of the mechanisms of regulating differentiation during remyelination and hence identifying novel therapeutic targets.

 









출처: SOT (Society of Toxicology) http://www.toxicology.org/education/pw/lec/AM16_MRC.asp
 


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