안녕하세요. CND 관리자입니다. 오늘 소개해 드릴 공부거리 주제는 A Phenotypic Platform for Chrarcterization of Drug Safety Mechanisms입니다. Webinar 녹화영상을 시청하실 수 있는 링크 및 자료를 게시해 드립니다. 감사합니다. https://youtu.be/VaHeY94Kn7M 출처: DiscoverX Corporation https://www.discoverx.com  

안녕하세요. CND 관리자입니다. 오늘의 공부거리는 생식기계 병리에 대한 ACT webniar 입니다. 웨비나 녹화 영상을 시청하실 수 있는 링크를 첨부합니다.      American College of Toxicology and Society of Toxicologic Pathology Collaboration Webinar Speakers: Christopher J. Bowman, PhD, DABT, Associate Research Fellow, Pfizer Worldwide R&D and Wendy G. Halpern, DVM, PhD, DACVP, Principal Pathologist, Genentech, Inc. Reproduction, Development, and Pathology: Finding Common Ground 출처: http://www.actox.org/meetCourses/eduWebinars.asp

안녕하세요, CND 관리자입니다. 오늘의 공부거리는 Robert Maronpot의 IATP (International Academy of Toxicology Pathology) 강의 "Adverse, Non-adverse and Adaptive Responses in Toxicologic Pathology" 입니다.  관련 슬라이드를 첨부합니다.   출처: https://focusontoxpath.com/adverse-responses/

안녕하세요. CND 관리자입니다. 이번 공부거리는 Focus on Tox Path 사이트에 게시된 간독성 전반에 대한 슬라이드 강의입니다. 출처: http://focusontoxpath.com/hepatotoxicity/  

안녕하세요 CND 센터 관리자입니다.  오늘은 in vitro 강연 시리즈 중 '약물 유도성 미토콘드리아 독성을 평가하기 위한 in vitro screening tools의 발전'을 주제로 한 강연을 소개해 드립니다. 영상자료 대신 발표 PPT를 파일로 첨부하였습니다.  부디 많은 참고 되시길 바랍니다. Yvonne Will Pfizer, Inc., San Diego, California It is estimated that only 50% of the animal studies predict human efficacy and more importantly human toxicity. In addition, the use of animals should be minimized as much as possible for ethical reasons. Today, there are vigorous, ongoing national and international research and policy efforts to develop alternatives to animal testing. The efforts focus on both in vitro and in silico approaches and methods. For example, the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS) created the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) in 1998. Mitochondrial dysfunction is a common mechanism of drug-induced toxicity for a variety of therapeutics, such as certain antiviral drugs, lipid-lowering drugs, NSAIDs and certain cancer chemotherapeutics. Therefore, the early identification of drug candidates that potentially disrupt mitochondrial function is of significant importance in drug discovery. In the past few years we have developed organelle and cell based in vitro screens to detect potential mitochondrial toxicities. These include oxygen sensors to measure mitochondrial respiration in isolated mitochondria and cells, immunocapture of individual electron transport chain proteins that can identify inhibitors of mitochondrial electron transport, and metabolic profiling using oxygen and pH measurements. We discuss the strength and limitations of new applicable high throughput screens and provide recommendations of where to position these assays within the drug development process.   출처: SOT (Society of Toxicology) http://www.toxicology.org/education/pw/ivLectures.asp  

안녕하세요. CND 센터 관리자입니다. 오늘은 안구의 독성병리를 주제로 교육을 소개해드리겠습니다. PDF 자료를 아래 파일로 첨부하였습니다. 부디 많은 참고가 되시길 바랍니다.   Pathology of the Posterior Segment in Ocular Toxicity Studies  Speaker: Steve Sorden   Safety studies of drug candidates designed to treat diseases of the retina are increasingly complex.  Unlike many other organs, multiple antemortem tools are available to evaluate and monitor the effects of drug candidates on ocular morphology.  Microscopic evaluation of the eye in toxicity studies must take into account multiple factors, including findings from various antemortem tests.  The speaker will focus on important points for pathologists to consider when evaluating the posterior segment of the eye in drug safety studies, including route of administration, ocular fixation, immunohistochemistry, and correlation of microscopic findings with findings from antemortem tests.    출처: http://www.ifstp.net/webinar_programs  

[Webinars] Pathology Techniques in Rat Neurotoxicity Studies 안녕하세요. CND 센터 관리자입니다. 오늘은 랫드의 신경독성을 주제로 Webinar 교육을 소개해드리겠습니다. 아래 링크를 누르신 이후 하단에 있는 Playback 버튼을 누르시면 Webinar player 프로그램인 WebEx를 통해 기록된 교육을 청취하실 수 있습니다. 수업 PDF 자료는 아래 파일로 첨부되어 있습니다. 부디 많은 참고가 되시길 바랍니다. Webinar 교육 링크     PATHOLOGY TECHNIQUES IN RAT NEUROTOXICITY STUDIES  HOSTED BY STP-I CO-SPONSORED BY IFSTP AND IATP  Held on May 11, 2015 Speaker:  Alok Sharma, BVSc, MVSc, MS, PhD, DACVP, DABT      Various pharmaceuticals drugs and environmental toxins have potential to cause neurotoxicity, which is manifested as an adverse effect on the structure and/or function of the nervous system. To screen for potential neurotoxicity in rats, a combination of techniques are used including functional observational battery (FOB), study of motor activity and histopathology. This webinar provided an overview of techniques used to detect histopathologicchanges in the central and peripheral nervous system. The speaker focused on important points to consider while designing and conducting neuropathological evaluation in rats including perfusion-fixation, collection of tissues (brain, spinal cord, dorsal root ganglia, peripheral nerves, and muscles), common embedding techniques and use of histochemical stains and immunohistochemical labels to detect histopathologicchanges.  출처: http://www.ifstp.net/webinar_programs

[Webinars] Update on Reproductive Toxicologic Pathology 안녕하세요. CND 센터 관리자입니다. 오늘은 생식 독성을 주제로 Webinar 교육을 소개해드리겠습니다. 아래 링크를 누르신 이후 하단에 있는 Playback 버튼을 누르시면 Webinar player 프로그램인 WebEx를 통해 기록된 교육을 청취하실 수 있습니다. 부디 많은 참고가 되시길 바랍니다. Webinar 교육 링크     Update on Reproductive Toxicologic Pathology   CO-SPONSORED BY IFSTP & IATP  Held on January 21, 2016 Speakers: Karen Regan and Justin Vidal      This webinar provided toxicologic pathologist throughout the Asia-Pacific region with a current issues update on the design of general toxicology studies specific to the interpretation of reproductive pathology findings from two highly-regarded experts.  Justin Vidal discussed the evaluation of the male reproductive system in nonhuman primates focusing on the determination of sexual maturity and common spontaneous findings.  Karen Regan described how to recognize early senescent changes in female rodents.  출처: http://www.ifstp.net/webinar_programs

[In vitro] The 3Rs in Animal Use and a Prospective In Vitro Screening Tool for Identifying Potential Immunotoxicants 안녕하세요. CND 센터 관리자입니다. 이번에는 immunotoxicants의 in vitro 접근방법을 주제로 강연을 소개해드리겠습니다. 영상자료 대신 PPT 자료를 파일로 첨부하였습니다.  조금이나마 학습에 도움이 되길 바랍니다.   Courtney E. W. Sulentic Wright State University, Dayton, Ohio The purpose of this lecture is to discuss the importance of animal research to biomedical sciences and toxicology and the ethical obligations of the scientific community to follow the “3Rs” of animal testing (refine, reduce, replace) whenever it is feasible. Following this discussion the remainder of the lecture will briefly describe Dr. Sulentic’s current research utilizing an in vitro alternative to understand mechanisms in altered immune function. The immune system is critical to human survival but also plays a contributing role in various mechanisms of toxicity. Assessing alterations of immune function by potential immunotoxicants is complicated by the diffuse nature of the immune system which is composed of various effector cells each with differing functions. Current immunotoxicity testing relies heavily on animal studies underscoring the need to develop and implement alternative approaches. Dr. Sulentic will discuss a cell line model developed to provide an in vitro alternative to animal studies in identifying immunotoxicants that specifically target B-cell function (i.e., alteration of immunoglobulin expression and antibody secretion) as well as elucidating the mechanisms of altered B-cell function. 출처: SOT http://www.toxicology.org/education/pw/ivLectures.asp  

[Webinars] Dermatopathology & Dermatotoxicology 안녕하세요. CND 센터 관리자입니다. 오늘 소개해드릴 주제는 피부 독성 입니다. 아래 링크를 누르신 이후 하단에 있는 Playback 버튼을 누르시면 Webinar player 프로그램인 WebEx를 통해 기록된 교육을 청취하실 수 있습니다. 부디 많은 참고가 되시길 바랍니다. Webinar 교육 링크     Dermatopathology & Dermatotoxicology HOSTED BY STP-I CO-SPONSORED BY IFSTP & IATP Speaker: Lars Mecklenburg, DVM, PhD, Dipl ACVP Covance Laboratories      This webinar presented an introduction into dermatopathology within the scope of toxicological risk assessments. Discussions will focus on the structure and function of the skin, mechanisms of toxicity, nomenclature for morphological changes and its application in hazard characterization.   출처: http://www.ifstp.net/webinar_programs

[Webinars] The Toxicologic Pathology of Common Kinase Targets 안녕하세요. CND 센터 관리자입니다. 오늘 소개해드릴 주제는 Kinase 표적으로하는 약물에서 관찰되는 조직학적 독성 반응 입니다. 아래 링크를 누르신 이후 하단에 있는 Playback 버튼을 누르시면 Webinar player 프로그램인 WebEx를 통해 기록된 교육을 청취하실 수 있습니다. 강연 슬라이드는 PDF 파일로 첨부하였습니다. 부디 많은 참고가 되시길 바랍니다. Webinar 교육 링크     The Toxicologic Pathology of Common Kinase Targets HOSTED BY STP-I CO-SPONSORED BY IFSTP & IATP Speaker: Timothy LaBranche DVM, PhD, DACVP Blueprint Medicines, Cambridge, MA    This webinar covered common toxicities associated with inhibition of cellular kinases by small molecule pharmaceuticals.  The human kinome is rich with targets for anticancer and immunomodulatory therapies and this presents an opportunity for toxicologists and pathologists to help the broader medical community by characterizing the roles that kinases play in tissue function. The goal of the presentation was to shed light on some of the tissue responses associated with common kinase targets, and to highlight future opportunities in understanding the role kinases play in health and disease. 출처: http://www.ifstp.net/webinar_programs

[Webinars] Using Electron Microscopy in Nonclinical Studies​ 안녕하세요. CND 센터 관리자입니다. 오늘 소개해드릴 주제는 비임상시험에서 전자현미경의 활용 방안 입니다. 아래 링크를 누르신 이후 하단에 있는 Playback 버튼을 누르시면 Webinar player 프로그램인 WebEx를 통해 기록된 교육을 청취하실 수 있습니다. 많은 참고가 되길 바랍니다. Webinar 교육 링크   Using Electron Microscopy in Nonclinical Studies Hosted by STP-I Co-sponsored by IFSTP and IATP May 25, 2017 Speaker: Thomas Steinbach, EPL Inc.   The webinar discussed the basic processes involved in collecting a sample and producing an image from transmission electron microscopy (TEM) suitable for interpretation in nonclinical studies.  The talk emphasized when it is appropriate to use TEM in a nonclinical setting, how to design a protocol that incorporates TEM and the limits of TEM analysis.    출처: http://www.ifstp.net/webinar_programs  

[SOT Lectures] The Symbiosis of Mentoring_Getting the Most out of the Mentor-Mentee Relationship 안녕하세요. CND 센터 관리자입니다. 독성학자에게 필요한 소양 중에서 Mentor-Mentee Relationship을 주제로 마지막 강연을 소개해드리겠습니다. 오늘 올려드리는 주제는 'Mentoring Interdisciplinary Scientists' 입니다. 많은 도움이 되길 바랍니다.   Chairperson(s): Kelly J. Chandler, US EPA, Research Triangle Park, NC, and Bethany R. Hannas, US EPA, Research Triangle Park, NC.   Mentoring is a critical element in the career development of all toxicologists, both in terms of making the most of potential mentors and developing effective mentoring skills. Whether through involvement in academia, or helping to develop the expertise of an early-career scientist, most toxicologists will provide mentoring at some point in their career. The mentor role serves to transfer knowledge, give advice and provide support to a trainee or developing scientist, while the mentee is relied upon by the mentor to provide active participation and input into the relationship. According to national polls, as well as SOT-specific surveys, one of the resounding topics of interest for developing scientists is mentoring from the broad perspectives of choosing the right mentor, down to developing the skills to become a sound mentor. Therefore, this session was designed to complement existing mentor matching opportunities offered through SOT. Speaker presentations will focus on: (1) the fundamentals of mentoring, including the different situations and roles in which the mentee-mentor dynamic may be encountered; (2) an introduction to the most commonly used mentoring techniques; (3) identifying characteristics of a strong mentor-mentee relationship; and (4) mentoring towards the future of science and the challenge to overcome more complex scientific problems. Speaker perspectives will address the mentorship role within academia, government, and industry. Attendees of this session will learn to identify a healthy mentor-mentee relationship and understand the benefits to each member of the collaboration. Mentoring topics discussed in this session will be applicable to scientists at every career stage through highlighting the basics behind a strong, mutually-beneficial mentoring relationship.     The Symbiosis of Mentoring: Getting the Most out of the Mentor-Mentee Relationship The Future: Mentoring Interdisciplinary Scientists Presenter: Ofelia A. Olivero 출처: SOT (Society of Toxicology) http://www.toxicology.org/education/pw/lectures.asp

[SOT Lectures] The Symbiosis of Mentoring_Getting the Most out of the Mentor-Mentee Relationship 안녕하세요. CND 센터 관리자입니다. 독성학자에게 필요한 소양 중에서 Mentor-Mentee Relationship을 주제로 강연 시리즈를 소개해드리겠습니다. 오늘 올려드리는 주제는 'The Two-Way Street of Mentoring: Reflections on Career Development in a Chemical Industry Toxicology Laboratory' 입니다. 이번 강연은 영상은 없지만 플레이어를 통해 강연 소리가 제공됩니다. 많은 도움이 되길 바랍니다.   Chairperson(s): Kelly J. Chandler, US EPA, Research Triangle Park, NC, and Bethany R. Hannas, US EPA, Research Triangle Park, NC.   Mentoring is a critical element in the career development of all toxicologists, both in terms of making the most of potential mentors and developing effective mentoring skills. Whether through involvement in academia, or helping to develop the expertise of an early-career scientist, most toxicologists will provide mentoring at some point in their career. The mentor role serves to transfer knowledge, give advice and provide support to a trainee or developing scientist, while the mentee is relied upon by the mentor to provide active participation and input into the relationship. According to national polls, as well as SOT-specific surveys, one of the resounding topics of interest for developing scientists is mentoring from the broad perspectives of choosing the right mentor, down to developing the skills to become a sound mentor. Therefore, this session was designed to complement existing mentor matching opportunities offered through SOT. Speaker presentations will focus on: (1) the fundamentals of mentoring, including the different situations and roles in which the mentee-mentor dynamic may be encountered; (2) an introduction to the most commonly used mentoring techniques; (3) identifying characteristics of a strong mentor-mentee relationship; and (4) mentoring towards the future of science and the challenge to overcome more complex scientific problems. Speaker perspectives will address the mentorship role within academia, government, and industry. Attendees of this session will learn to identify a healthy mentor-mentee relationship and understand the benefits to each member of the collaboration. Mentoring topics discussed in this session will be applicable to scientists at every career stage through highlighting the basics behind a strong, mutually-beneficial mentoring relationship.     The Symbiosis of Mentoring: Getting the Most out of the Mentor-Mentee Relationship The Two-Way Street of Mentoring: Reflections on Career Development in a Chemical Industry Toxicology Laboratory Presenter: Louise Saldutti 출처: SOT (Society of Toxicology) http://www.toxicology.org/education/pw/lectures.asp

[SOT Lectures] The Symbiosis of Mentoring_Getting the Most out of the Mentor-Mentee Relationship 안녕하세요. CND 센터 관리자입니다. 이번에는 독성학자에게 필요한 소양 중에서 Mentor-Mentee Relationship을 주제로 강연 시리즈를 소개해드리겠습니다. 오늘 올려드리는 주제는 'Approaches for Mentoring Graduate Students' 입니다. 많은 도움이 되길 바랍니다.   Chairperson(s): Kelly J. Chandler, US EPA, Research Triangle Park, NC, and Bethany R. Hannas, US EPA, Research Triangle Park, NC.   Mentoring is a critical element in the career development of all toxicologists, both in terms of making the most of potential mentors and developing effective mentoring skills. Whether through involvement in academia, or helping to develop the expertise of an early-career scientist, most toxicologists will provide mentoring at some point in their career. The mentor role serves to transfer knowledge, give advice and provide support to a trainee or developing scientist, while the mentee is relied upon by the mentor to provide active participation and input into the relationship. According to national polls, as well as SOT-specific surveys, one of the resounding topics of interest for developing scientists is mentoring from the broad perspectives of choosing the right mentor, down to developing the skills to become a sound mentor. Therefore, this session was designed to complement existing mentor matching opportunities offered through SOT. Speaker presentations will focus on: (1) the fundamentals of mentoring, including the different situations and roles in which the mentee-mentor dynamic may be encountered; (2) an introduction to the most commonly used mentoring techniques; (3) identifying characteristics of a strong mentor-mentee relationship; and (4) mentoring towards the future of science and the challenge to overcome more complex scientific problems. Speaker perspectives will address the mentorship role within academia, government, and industry. Attendees of this session will learn to identify a healthy mentor-mentee relationship and understand the benefits to each member of the collaboration. Mentoring topics discussed in this session will be applicable to scientists at every career stage through highlighting the basics behind a strong, mutually-beneficial mentoring relationship.     The Symbiosis of Mentoring: Getting the Most out of the Mentor-Mentee Relationship Approaches for Mentoring Graduate Students Presenter: Stephen Safe  출처: SOT (Society of Toxicology) http://www.toxicology.org/education/pw/lectures.asp