Asan Medical center, Seoul, Professor Woochan Son’s Laboratory

Service Overview Advisory Expert Network Service Procedures Operational Policy Q&A

The Non-clinical Development Center provides services to accurately identify non-clinical safety issues related to substances under development. When necessary, we conduct hypothesis-driven experiments and offer solutions through comprehensive data analysis conducted by experts from various disciplines.

Strategic Planning for Risk Management

Execution of Experiments

Data Analysis

Toxicity Issue Solution
Development Go/No-Go Decision

Reflected in the Overview Document

Type 1

Mechanism
Identification Test

Knowledge-Based Approach.

If non-clinical safety issues can be explained and resolved through various literature sources and past cases, the results are presented as an expert report.

Type 2

Solution Derived from Existing Knowledge
(Experience, Knowledge, Literature Review, etc.)

Conducting Additional Testing

If additional assays are required to accurately identify non-clinical safety issues, various assays are conducted to seek a resolution.

Type 3

Hypothesis-driven Study for MoA

Establishing a new hypothesis and designing appropriate tests.

Conducting hypothesis-driven tests to identify and resolve non-clinical safety issues.

Development and Distribution of Risk Management Algorithms

List of Available Services.

Toxicity Evaluation (Rodents and Non-Rodents) Provision of GEM (Genetically Engineered Mice) PK-PD Modeling and Simulation Bio-imaging Metabolomics-based toxicity assessment 3D Organoid-Based Mini-Organ Toxicity Assessment Species-Specific Comparative Metabolite Toxicity Assessment and Selection of Test Animal Species for Toxicity Evaluation On/Off-Target Liability Assessment Using GEM Models HTS (High-Throughput Screening) Using HCS (High-Content Screening) AOP(Adverse Outcome Pathway) Research KIT(Korea Institute of Toxicology) - Cardiac toxicity assessment KIT(Korea Institute of Toxicology) – In silico-based toxicity prediction