Pathology of the Posterior Segment in Ocular Toxicity Studies 

Speaker: Steve Sorden

 

Safety studies of drug candidates designed to treat diseases of the retina are increasingly complex.  Unlike many other organs, multiple antemortem tools are available to evaluate and monitor the effects of drug candidates on ocular morphology.  Microscopic evaluation of the eye in toxicity studies must take into account multiple factors, including findings from various antemortem tests.  The speaker will focus on important points for pathologists to consider when evaluating the posterior segment of the eye in drug safety studies, including route of administration, ocular fixation, immunohistochemistry, and correlation of microscopic findings with findings from antemortem tests.