[Webinars] Progress Made on Tox21: A Framework for the Next Generation of Risk Science
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Moderator: Daniel Krewski, PhD, MHA, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa
On October 1, 2014, the Scientific Liaison Coalition (SLC) hosted a webinar, Progress Made on Tox21: A Framework for the Next Generation of Risk Science, presented by Daniel Krewski. The Society of Toxicology (SOT) is a participating member of the SLC. Dr. Krewski is currently Professor of Epidemiology and Community Medicine and Scientific Director of the McLaughlin Centre for Population Health Risk Assessment at the University of Ottawa. He served as Chair of the National Research Council’s Committee on Toxicity Testing and Assessment of Environmental Agents, which published its influential report, “Toxicity Testing in the 21st Century: A Vision and a Strategy,” published in June of 2007.
The mission of the SLC is “improving the ability of societies to partner with other domestic and international organizations that have objectives consistent with the goal of increasing the impact of the science of toxicology to improve public health“ by:
- - Strengthening partnerships among scientific- and health-based organizations to increase awareness of the impact of toxicology and related subjects on human health, and
- - Functioning as a means to enhance cooperation among societies as equals with the goal of accomplishing tasks benefiting human health and disease prevention through joint and several shared activities.
The participating societies in the SLC include the American Association for Cancer Research (AACR), American Academy of Clinical Toxicology (AACT), American Chemical Society (ACS), American College of Medical Toxicology (ACMT), American College of Toxicology (ACT), The Endocrine Society (ENDO), Environmental Mutagenesis and Genomics Society (EMGS), International Society for the Study of Xenobiotics (ISSX), Safety Pharmacology Society (SPS), Society for Risk Analysis (SRA), Society for the Study of Reproduction (SSR), Society of Environmental Toxicology and Chemistry (SETAC), Society of Toxicologic Pathology (STP), SOT, and Teratology Society (Teratology).
Webinar 교육 소개 내용 입니다.
| Topic: |
Progress Made on Tox21: A Framework for the Next Generation of Risk Science
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| Recording date: |
Wednesday, October 1, 2014 12:01 pm |
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Eastern Daylight Time (New York, GMT-04:00) |
| Panelist Information: |
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| Duration: |
1 hour 12 minutes |
| Descr!ption: |
Progress Made on Tox21:
A Framework for the Next Generation of Risk Science
Daniel Krewski, PhD, MHA
Professor and Director
McLaughlin Centre for Population Health Risk Assessment
University of Ottawa
In 2007, the US National Research Council (NRC) published a ground‒breaking report entitled Toxicity Testing in the 21st Century: a Vision and a Strategy. The purpose of this report was to develop a long‒ range strategic plan to update and advance the way environmental agents are tested for toxicity. The vision focused on the identification of critical perturbations of toxicity pathways that lead to adverse human health outcomes using modern scientific tools and technologies. The strategy was designed to greatly increase our capacity for toxicity testing, using techniques such as high‒throughput in vitro screening assays to detect critical toxicity pathway perturbations. Implementation of the NRC vision was expected to take 10 to 20 years or longer to complete, and would involve a major effort to map the toxicity pathways by which environmental agents may cause adverse health outcomes.
This presentation takes stock of progress made in the now seven years since the NRC articulated its vision for the future of toxicity testing. The vision has been widely endorsed by agencies within the United States, including the formation of the Tox21 consortium of four federal agencies that have agreed to work together to operationalize the NRC vision. The NRC vision also has attracted considerable attention internationally, with initiatives focusing on advancing the vision now underway in Canada, the European Union, and China. Case studies indicate that substantial progress has been made on implementing the NRC vision, and that a number of key elements of the vision are beginning to find application in risk assessment practice.
To support the paradigm shift in toxicological risk assessment embodied in the NRC vision, new risk assessment and new exposure assessment methodologies also are required. In 2014, the EPA proposed a framework for the next generation of risk science, based on three cornerstones: TT21C, new risk assessment methodologies, and a population health approach to human health risk assessment. High‒throughput exposomics also are important to the future of risk science.
Further collaboration at the international level will serve to foster a coordinated approach to risk science in the 21st century (RS21C), and ensure that human health risk assessment is based on the best available tools, technologies, and methodologies available to the scientific community
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출처: SOT (Society of Toxicology) http://www.toxicology.org/education/pw/lectures.asp
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